The present disclosure provides a leakage protection circuit, a method and a drive device. The leakage protection circuit is used for being electrically connected with the power supply line of a load, and may be configured to sample the power supply line at intervals, detect the voltage of the sampled electrical signals to determine whether the voltage of the AC input power is divided, and provide leakage protection based on the determined result. The present disclosure can prevent human from electric shock through sampling the electric signals from the power supply line at intervals and performing voltage detection and comparasion to determine whether the voltage of the accessed AC input power is divided, when the voltage of the accessed AC input power is determined to be divided, the power supply line will be controlled in non-conductive state.