We disclose a device and method for collecting a urine sample as a user urinates into a toilet. The device further conducts analytical measurements which may include spectral, colorimetric, and chemical assays. The user need only urinate normally into the toilet. A urine collection trap, which includes a vertical slit, may capture a urine sample which has a volume in the microliter range. Pumps may divert the urine from the vertical slit into a conduit that is connected to spectral analysis devices and other devices for analyzing the urine sample. The disclosed device is both convenient and prevents unsanitary urine spills.