The present application provides a three-axis linkage embroidery machine frame and an embroidery machine. The three-axis linkage embroidery machine frame includes a supporting frame, an X-axis driving mechanism, a Y-axis driving mechanism and a Z-axis driving mechanism. The X-axis driving mechanism is arranged on the supporting frame, the Y-axis driving mechanism is respectively coupled with the X-axis driving mechanism and the Z-axis driving mechanism. The advantageous effect of the present application is that, through the linkage of the X-axis driving mechanism, the Y-axis driving mechanism and the Z-axis driving mechanism, not only can the embroidery product be driven to move in the directions of the X-axis and the Y-axis, but also the embroidery product can be driven to rotate 360°, so that it is possible to avoid that the embroidery direction is the same as the thread taking direction of the rotating shuttle when embroidering.