- 专利标题： Antibodies binding to HLA-A2/MAGE-A4
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申请号： US17125500申请日： 2020-12-17
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公开(公告)号： US20210230278A1公开(公告)日： 2021-07-29
- 发明人: Tina Weinzierl , Lydia Jasmin Hanisch , Alexander Bujotzek , Alejandro Carpy Gutierrez Cirlos , Stefan Klostermann , Christian Klein , Simon Patrick Keiser , Tanja Fauti , Estelle Marrer-Berger , Pablo Umaña
- 申请人： Hoffmann-La Roche Inc.
- 申请人地址： US NJ Little Falls
- 专利权人： Hoffmann-La Roche Inc.
- 当前专利权人： Hoffmann-La Roche Inc.
- 当前专利权人地址： US NJ Little Falls
- 优先权： EP19217463.9 20191218
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; C07K16/30 ; A61P35/00
摘要：
The present invention generally relates to antibodies that bind to HLA-A2/MAGE-A4, including multispecific antibodies e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.
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