公开(公告)号：US20210230278A1

公开(公告)日：2021-07-29

申请号：US17125500

申请日：2020-12-17

Applicant: Hoffmann-La Roche Inc.

Inventor： Tina Weinzierl ,  Lydia Jasmin Hanisch ,  Alexander Bujotzek ,  Alejandro Carpy Gutierrez Cirlos ,  Stefan Klostermann ,  Christian Klein ,  Simon Patrick Keiser ,  Tanja Fauti ,  Estelle Marrer-Berger ,  Pablo Umaña

IPC: C07K16/28 ,  C07K16/30 ,  A61P35/00

Abstract: The present invention generally relates to antibodies that bind to HLA-A2/MAGE-A4, including multispecific antibodies e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.

公开(公告)号：US11987632B2

公开(公告)日：2024-05-21

申请号：US17125500

申请日：2020-12-17

Applicant: Hoffmann-La Roche Inc.

Inventor： Tina Weinzierl ,  Lydia Jasmin Hanisch ,  Alexander Bujotzek ,  Alejandro Carpy Gutierrez Cirlos ,  Stefan Klostermann ,  Christian Klein ,  Simon Patrick Keiser ,  Tanja Fauti ,  Estelle Marrer-Berger ,  Pablo Umaña

IPC: C07K16/28 ,  A61P35/00 ,  C07K16/30 ,  A61K39/00

CPC classification number: C07K16/2833 ,  A61P35/00 ,  C07K16/2809 ,  C07K16/30 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/92

Abstract: The present invention generally relates to antibodies that bind to HLA-A2/MAGE-A4, including multispecific antibodies e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.

公开(公告)号：US11780919B2

公开(公告)日：2023-10-10

申请号：US17218948

申请日：2021-03-31

Applicant: Hoffmann-La Roche Inc.

Inventor： Maria Amann ,  Juergen Peter Bachl ,  Alexander Bujotzek ,  Carina Cantrill ,  Harald Duerr ,  Janine Faigle ,  Sabine Imhof-Jung ,  Christian Klein ,  Thomas Kraft ,  Estelle Marrer-Berger ,  Ekkehard Moessner ,  Laurene Pousse ,  Petra Rueger ,  Johannes Sam ,  Roland Staack ,  Dietrich Tuerck ,  Pablo Umana ,  Joerg Zielonka

IPC: A61K39/00 ,  C07K16/28 ,  A61P35/00 ,  A61K45/06 ,  C07K16/30 ,  C07K16/46

CPC classification number: C07K16/2809 ,  A61K45/06 ,  A61P35/00 ,  C07K16/2878 ,  C07K16/30 ,  C07K16/468 ,  A61K2039/505 ,  C07K2317/565 ,  C07K2317/622

Abstract: The invention relates to novel bispecific antigen binding molecules, comprising at least two antigen binding domains capable of specific binding to OX40 and a particular antigen binding domain capable of specific binding to Fibroblast Activation Protein (FAP), and to methods of producing these molecules and to methods of using the same.