- 专利标题： MULTICOMPONENT DEGRADABLE CATIONIC POLYMERS
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申请号： US17150796申请日： 2021-01-15
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公开(公告)号： US20210252154A1公开(公告)日： 2021-08-19
- 发明人: Jordan J. Green , Joel C. Sunshine , Nupura S. Bhise , Ron B. Shmueli , Stephany Y. Tzeng
- 申请人： The Johns Hopkins University
- 申请人地址： US MD Baltimore
- 专利权人： The Johns Hopkins University
- 当前专利权人： The Johns Hopkins University
- 当前专利权人地址： US MD Baltimore
- 主分类号： A61K47/20
- IPC分类号： A61K47/20 ; C08F222/10 ; C08G73/02 ; A61K38/02 ; A61K31/713 ; C07C323/25 ; C12N15/88 ; A61K9/107 ; C07C229/12 ; A61K48/00
摘要：
Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure provides significant changes to efficacy in a cell-type dependent manner. Polymers presented here are more effective than commercially available materials, such as LIPOFECTAMINE 2000™, FUGENE®, or polyethylenimine (PEI), for gene delivery to cancerous fibroblasts or human primary fibroblasts. The presently disclosed materials may be useful for cancer therapeutics and regenerative medicine.
公开/授权文献
- US12049530B2 Multicomponent degradable cationic polymers 公开/授权日：2024-07-30
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