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公开(公告)号:US20150250881A1
公开(公告)日:2015-09-10
申请号:US14644397
申请日:2015-03-11
IPC分类号: A61K47/20 , C08F222/10 , A61K38/02 , C07C323/25 , A61K31/713
CPC分类号: A61K47/20 , A61K9/1075 , A61K31/713 , A61K38/02 , A61K48/00 , C07C229/12 , C07C323/25 , C08F222/1006 , C08F2222/1013 , C08G73/028 , C12N15/88
摘要: Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure provides significant changes to efficacy in a cell-type dependent manner. Polymers presented here are more effective than commercially available materials, such as LIPOFECTAMINE 2000™, FUGENE®, or polyethylenimine (PEI), for gene delivery to cancerous fibroblasts or human primary fibroblasts. The presently disclosed materials may be useful for cancer therapeutics and regenerative medicine.
摘要翻译: 合成可降解的聚合物,其与DNA自组装形成对基因递送有效的颗粒。 聚合物合成条件,颗粒制剂条件和聚合物结构的小变化提供了细胞类型依赖方式的功效的显着变化。 这里提供的聚合物比商业上可获得的材料(例如LIPOFECTAMINE 2000 TM,FUGENE或聚乙烯亚胺(PEI))更有效,用于向癌性成纤维细胞或人原发性成纤维细胞的基因递送。 目前公开的材料可用于癌症治疗剂和再生药物。
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公开(公告)号:US12049530B2
公开(公告)日:2024-07-30
申请号:US17150796
申请日:2021-01-15
IPC分类号: C08F222/10 , A61K9/107 , A61K31/713 , A61K38/02 , A61K47/20 , A61K48/00 , C07C229/12 , C07C323/25 , C08G73/02 , C12N15/88
CPC分类号: C08F222/102 , A61K9/1075 , A61K31/713 , A61K38/02 , A61K47/20 , C07C229/12 , C07C323/25 , C08G73/028 , C12N15/88 , A61K48/00
摘要: Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure provides significant changes to efficacy in a cell-type dependent manner. Polymers presented here are more effective than commercially available materials, such as LIPOFECTAMINE 2000™, FUGENE®, or polyethylenimine (PEI), for gene delivery to cancerous fibroblasts or human primary fibroblasts. The presently disclosed materials may be useful for cancer therapeutics and regenerative medicine.
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公开(公告)号:US20200297851A1
公开(公告)日:2020-09-24
申请号:US16895596
申请日:2020-06-08
IPC分类号: A61K47/20 , C07C229/12 , C07C323/25 , C08G73/02 , C12N15/88 , A61K9/107 , A61K31/713 , A61K38/02 , C08F222/10
摘要: Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure provides significant changes to efficacy in a cell-type dependent manner. Polymers presented here are more effective than commercially available materials, such as LIPOFECTAMINE 2000™, FUGENE®, or polyethylenimine (PEI), for gene delivery to cancerous fibroblasts or human primary fibroblasts. The presently disclosed materials may be useful for cancer therapeutics and regenerative medicine.
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公开(公告)号:US20180177881A1
公开(公告)日:2018-06-28
申请号:US15821368
申请日:2017-11-22
IPC分类号: A61K47/20 , C12N15/88 , C08G73/02 , C07C323/25 , A61K31/713 , C08F222/10 , A61K9/107 , C07C229/12 , A61K38/02 , A61K48/00
CPC分类号: A61K47/20 , A61K9/1075 , A61K31/713 , A61K38/02 , A61K48/00 , C07C229/12 , C07C323/25 , C08F222/1006 , C08F2222/1013 , C08G73/028 , C12N15/88
摘要: Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure provides significant changes to efficacy in a cell-type dependent manner. Polymers presented here are more effective than commercially available materials, such as LIPOFECTAMINE 2000™, FUGENE®, or polyethylenimine (PEI), for gene delivery to cancerous fibroblasts or human primary fibroblasts. The presently disclosed materials may be useful for cancer therapeutics and regenerative medicine.
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公开(公告)号:US20210252154A1
公开(公告)日:2021-08-19
申请号:US17150796
申请日:2021-01-15
IPC分类号: A61K47/20 , C08F222/10 , C08G73/02 , A61K38/02 , A61K31/713 , C07C323/25 , C12N15/88 , A61K9/107 , C07C229/12 , A61K48/00
摘要: Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure provides significant changes to efficacy in a cell-type dependent manner. Polymers presented here are more effective than commercially available materials, such as LIPOFECTAMINE 2000™, FUGENE®, or polyethylenimine (PEI), for gene delivery to cancerous fibroblasts or human primary fibroblasts. The presently disclosed materials may be useful for cancer therapeutics and regenerative medicine.
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公开(公告)号:US09884118B2
公开(公告)日:2018-02-06
申请号:US14644397
申请日:2015-03-11
IPC分类号: A61K47/20 , C08F222/10 , A61K38/02 , C07C323/25 , A61K31/713 , A61K9/107 , C07C229/12 , C08G73/02 , C12N15/88 , A61K48/00
CPC分类号: A61K47/20 , A61K9/1075 , A61K31/713 , A61K38/02 , A61K48/00 , C07C229/12 , C07C323/25 , C08F222/1006 , C08F2222/1013 , C08G73/028 , C12N15/88
摘要: Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure provides significant changes to efficacy in a cell-type dependent manner. Polymers presented here are more effective than commercially available materials, such as LIPOFECTAMINE 2000™, FUGENE®, or polyethylenimine (PEI), for gene delivery to cancerous fibroblasts or human primary fibroblasts. The presently disclosed materials may be useful for cancer therapeutics and regenerative medicine.
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