A method of processing print jobs on a printing substrate processing machine by using a computer, includes creating a data model for the computer with parameters for an unusable print/set-up time prediction on the basis of global print jobs and printing machine data, training the data model on the basis of global and/or local print jobs and printing machine data by using the computer, and defining ease-of-use criteria by an operator. The trained data model for the computer is used to predict the number of unusable prints during set up and set-up time of the printing substrate processing machine. The order of the processing of the print jobs is optimized on the basis of the predicted number of unusable prints during set-up and the predicted set-up time by using the computer.