Invention Application
- Patent Title: (4-HYDROXYPYRROLIDIN-2-YL)-HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF
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Application No.: US16858004Application Date: 2020-04-24
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Publication No.: US20210309660A1Publication Date: 2021-10-07
- Inventor: Nicole Blaquiere , Peter Dragovich , Lewis J. Gazzard , Thomas Pillow , Steven T. Staben , Binqing Wei , Jianfeng Xin
- Applicant: Genentech, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Priority: CNPCT/CN2017/107445 20171024,CNPCT/CN2018/105402 20180913
- Main IPC: C07D471/16
- IPC: C07D471/16 ; C07D493/10 ; C07D403/04 ; C07D417/14 ; C07D413/14 ; A61P35/00
Abstract:
The present disclosure relates to bifunctional compounds, which can be used as modulators of targeted ubiquitination. In particular, the present disclosure is directed to compounds which contain on one end a VHL ligand moiety, which binds to the VHL E3 ubiquitin ligase, and on the other end a moiety that binds a target protein such that degradation of the target protein/polypeptide is effectuated. Also disclosed are VHL ligands.
Public/Granted literature
- US11242344B2 (4-hydroxypyrrolidin-2-yl)-heterocyclic compounds and methods of use thereof Public/Granted day:2022-02-08
Information query
