Sepsis is one of the most prevalent causes of mortality in Intensive Care Units (ICUs) and delayed treatment is associated with increase in death and financial burden. There is no single laboratory test or clinical sign that by itself can be considered diagnostic of sepsis. The present disclosure provides discriminating domain specific continuous and categorical features that can reliably classify a subject being monitored into a sepsis class or a normal class. A combination of physiological parameters, laboratory parameters and demographic details are used to extract the discriminating features. Even though the parameters may be sporadic in nature, the systems and methods of the present disclosure make use of a sliding time window to generate continuous features that capture the trend in the sporadic data; and a binning approach to generate categorical features to discriminate deviation from the normal class and facilitate timely treatment.