METHOD AND SYSTEM FOR EVALUATING CLINICAL EFFICACY OF MULTI-LABEL MULTI-CLASS COMPUTATIONAL DIAGNOSTIC MODELS

    公开(公告)号:US20240096492A1

    公开(公告)日:2024-03-21

    申请号:US18367546

    申请日:2023-09-13

    CPC classification number: G16H50/20

    Abstract: The present invention relates to the field of evaluating clinical diagnostic models. Conventional metrics does not consider context dependent clinical principles and is unable to capture critically important features that ought to be present in a diagnostic model. Thus, present disclosure provides a method and system for evaluating clinical efficacy of multi-label multi-class computational diagnostic models. Diagnosis for a given dataset of diagnostic samples is obtained from the diagnostic model which is then classified as wrong, missed, over or right diagnosis, based on which a first penalty is calculated. A second penalty is calculated for each diagnostic sample using a contradiction matrix. The first and second penalties are summed up to compute a pre-score for each diagnostic sample. Finally, the diagnostic model is evaluated using a metric that is based on sum of pre-scores, and scores from a perfect and a null multi-label multi-class computational diagnostic model.

    DISCRIMINATING FEATURES BASED SEPSIS PREDICTION

    公开(公告)号:US20210315511A1

    公开(公告)日:2021-10-14

    申请号:US17117375

    申请日:2020-12-10

    Abstract: Sepsis is one of the most prevalent causes of mortality in Intensive Care Units (ICUs) and delayed treatment is associated with increase in death and financial burden. There is no single laboratory test or clinical sign that by itself can be considered diagnostic of sepsis. The present disclosure provides discriminating domain specific continuous and categorical features that can reliably classify a subject being monitored into a sepsis class or a normal class. A combination of physiological parameters, laboratory parameters and demographic details are used to extract the discriminating features. Even though the parameters may be sporadic in nature, the systems and methods of the present disclosure make use of a sliding time window to generate continuous features that capture the trend in the sporadic data; and a binning approach to generate categorical features to discriminate deviation from the normal class and facilitate timely treatment.

    SYSTEMS AND METHODS FOR ATRIAL FIBRILLATION (AF) AND CARDIAC DISORDERS DETECTION FROM BIOLOGICAL SIGNALS

    公开(公告)号:US20210290175A1

    公开(公告)日:2021-09-23

    申请号:US17203578

    申请日:2021-03-16

    Abstract: Continuous monitoring of subject's cardiac system using biological signal(s) (BS) during day-to-day activities is essential for managing personal cardiac health/disorders, etc. Conventional systems/methods lack in improvising overall classification results and configured for specific device/signal say ECG or PPG and so on. Present disclosure provides systems and methods for classifying BS obtained from users, wherein BS are preprocessed to obtain filtered signals (FS). Corresponding feature extraction module is utilized for feature set extraction based on features in FS. The feature set is reduced and segmented into test and training data. Biological signal classification model(s) are generated using training data and a BCM is applied on test data to classify biological signals (BS) as one of Atrial Fibrillation (AF), a non-AF, a cardiac arrythmia disorder, or ischemia. Accelerometer features of connected device associated with the users can be obtained to detect activities which in conjunction with the BCM's output improvises above classification.

    NEUROMODULATION BASED ADAPTIVE CONTROLLER FOR MITRAL STENOSIS

    公开(公告)号:US20210280319A1

    公开(公告)日:2021-09-09

    申请号:US17149059

    申请日:2021-01-14

    Abstract: This disclosure provides a simulation platform to study and perform predictive analysis on valvular heart disease, Mitral stenosis (MS) and provides a control approach to correct hemodynamic imbalances during MS conditions. Conventional approaches of valve repair or replacement are often associated with risk of thromboembolism, need for anticoagulation, prosthetic endocarditis, and impaired left ventricle function. The cardiovascular hemodynamics model of the present disclosure helps to create ‘what if’ conditions to study variations in different hemodynamic parameters like blood flow, aortic and ventricular pressure, etc. during normal and pathological conditions. An adaptive control system in conjunction with the hemodynamic cardiovascular system (CVS) is provided to handle hemodynamic disbalance during moderate to severe MS conditions. The adaptive controller is hypothesized in line with the neuromodulation approach and modulates left ventricular contractility and vagal tone to counter the symptoms associated with MS.

Patent Agency Ranking