- 专利标题： METHODS AND COMPOSITIONS FOR STIMULATION OF CHIMERIC ANTIGEN RECEPTOR T CELLS WITH HAPTEN LABELLED CELLS
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申请号： US17265484申请日： 2019-08-02
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公开(公告)号： US20210317407A1公开(公告)日： 2021-10-14
- 发明人: Michael C. Jensen , James F. Matthaei
- 申请人： Seattle Children's Hospital (dba Seattle Children's Research Institute)
- 申请人地址： US WA Seattle
- 专利权人： Seattle Children's Hospital (dba Seattle Children's Research Institute)
- 当前专利权人： Seattle Children's Hospital (dba Seattle Children's Research Institute)
- 当前专利权人地址： US WA Seattle
- 国际申请： PCT/US19/44981 WO 20190802
- 主分类号： C12N5/0783
- IPC分类号： C12N5/0783 ; A61K35/17 ; C07K16/44 ; C07K14/73 ; C07K14/705 ; C07K16/28
摘要：
Some embodiments of the methods and compositions provided herein relate to the use of hapten labeled cells to stimulate chimeric antigen receptor (CAR) T cells. In some embodiments, CAR T cells can include a CAR that specifically binds to a hapten. Some embodiments relate to the in vivo or in vitro stimulation CAR T cells by hapten labeled cells.
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