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公开(公告)号:US20230172981A1
公开(公告)日:2023-06-08
申请号:US17758960
申请日:2021-02-02
IPC分类号: A61K35/17 , C07K14/725
CPC分类号: A61K35/17 , C07K14/7051
摘要: Some embodiments of the methods and compositions provided herein relate to the use of hapten labeled cells to stimulate chimeric antigen receptor (CAR) T cells. In some embodiments, CAR T cells can include a CAR that specifically binds to a hapten. Some embodiments relate to the in vivo or in vitro stimulation CAR T cells by hapten labeled cells.
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公开(公告)号:US20230068879A1
公开(公告)日:2023-03-02
申请号:US17758959
申请日:2021-02-02
IPC分类号: C07K14/725
摘要: Embodiments provided herein include methods and compositions comprising anti-dinitrophenol chimeric antigen receptors (CARs). Some embodiments include nucleic acids encoding such CARs, polypeptides encoded by such nucleic acids, cells comprising such nucleic acids or polypeptides, and methods utilizing such cells. Some embodiments also include the use of dinitrophenol (DNP) and derivatives thereof.
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公开(公告)号:US20210317407A1
公开(公告)日:2021-10-14
申请号:US17265484
申请日:2019-08-02
IPC分类号: C12N5/0783 , A61K35/17 , C07K16/44 , C07K14/73 , C07K14/705 , C07K16/28
摘要: Some embodiments of the methods and compositions provided herein relate to the use of hapten labeled cells to stimulate chimeric antigen receptor (CAR) T cells. In some embodiments, CAR T cells can include a CAR that specifically binds to a hapten. Some embodiments relate to the in vivo or in vitro stimulation CAR T cells by hapten labeled cells.
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