- 专利标题： SIRT4 Lipoamidase Activity and Uses Thereof
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申请号： US16991429申请日： 2020-08-12
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公开(公告)号： US20210318312A1公开(公告)日： 2021-10-14
- 发明人: Thomas Shenk , Todd M. Greco , Ileana M. Cristea , Rommel A. Mathias , Adam Oberstein
- 申请人： THE TRUSTEES OF PRINCETON UNIVERSITY
- 申请人地址： US NJ Princeton
- 专利权人： THE TRUSTEES OF PRINCETON UNIVERSITY
- 当前专利权人： THE TRUSTEES OF PRINCETON UNIVERSITY
- 当前专利权人地址： US NJ Princeton
- 主分类号： G01N33/573
- IPC分类号： G01N33/573 ; C12Q1/34
摘要：
The present application demonstrates that sirtuin 4 (SIRT4) acts as a cellular lipoamidase that negatively regulates pyruvate dehydrogenase complex (PDHC) activity through hydrolysis of its lipoamide cofactors.
公开/授权文献
- US11726088B2 Sirtuin 4 (SIRT4) lipoamidase activity and uses thereof 公开/授权日：2023-08-15
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