- 专利标题： AFFIBODY PROTEINS SPECIFIC FOR B7-H3 (CD276)
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申请号： US17267733申请日： 2019-08-22
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公开(公告)号： US20210340257A1公开(公告)日： 2021-11-04
- 发明人: Lotfi Abou-Elkacem , Juergen Karl Willmann , Benjamin J. Hackel , Lawrence Arthur Stern , Patrick Samuel Lown , Amelie Margarete Marianne Lutz , Rakesh Kumar Bam
- 申请人： Lotfi Abou-Elkacem , Juergen Karl Willmann , Benjamin J. Hackel , Lawrence Arthur Stern , Patrick Samuel Lown , Amelie Margarete Marianne Lutz , Rakesh Kumar Bam , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , REGENTS OF THE UNIVERSITY OF MINNESOTA
- 申请人地址： US TX Houston; US CA Stanford; US MN Edina; US CA Monrovia; US MN Minneapolis; US CA Stanford; US CA Menlo Park; US CA Stanford; US MN Minneapolis
- 专利权人： Lotfi Abou-Elkacem,Juergen Karl Willmann,Benjamin J. Hackel,Lawrence Arthur Stern,Patrick Samuel Lown,Amelie Margarete Marianne Lutz,Rakesh Kumar Bam,THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY,REGENTS OF THE UNIVERSITY OF MINNESOTA
- 当前专利权人： Lotfi Abou-Elkacem,Juergen Karl Willmann,Benjamin J. Hackel,Lawrence Arthur Stern,Patrick Samuel Lown,Amelie Margarete Marianne Lutz,Rakesh Kumar Bam,THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY,REGENTS OF THE UNIVERSITY OF MINNESOTA
- 当前专利权人地址： US TX Houston; US CA Stanford; US MN Edina; US CA Monrovia; US MN Minneapolis; US CA Stanford; US CA Menlo Park; US CA Stanford; US MN Minneapolis
- 国际申请： PCT/US2019/047764 WO 20190822
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; A61K47/68 ; A61K49/22 ; A61K9/00 ; A61P35/00
摘要：
Affibody polypeptides that specifically bind to B7-H3 are provided. Exemplary anti-B7-H3 affibodies are provided. The affibody polypeptides specifically recognize and bind to B7-H3 with high affinity. The affibodies can be conjugated to contrast agents, including without limitation microbubbles for contrast-enhanced ultrasound imaging