Systems and methods are disclosed for control voltage profiles, line flows and transmission losses of a power grid by forming an autonomous multi-objective control model with one or more neural networks as a Deep Reinforcement Learning (DRL) agent; training the DRL agent to provide data-driven, real-time and autonomous grid control strategies; and coordinating and optimizing power controllers to regulate voltage profiles, line flows and transmission losses in the power grid with a Markov decision process (MDP) operating with reinforcement learning to control problems in dynamic and stochastic environments.