Devices, systems, and methods are provided in which noise or artifacts generated by motion of a probe are attenuated in acquired physiological data, such as auscultation or ultrasound data. One such method includes acquiring physiological data of a patient by a handheld device. Motion of the handheld device is sensed, and a determination is made as to whether the sensed motion of the handheld device exceeds a motion threshold. The method further includes generating conditioned physiological data of the patient by attenuating a portion of the acquired physiological data in response to determining that the sensed motion of the handheld device exceeds the motion threshold.