In various embodiments, the disclosed system may be utilized in managing supply and demand chains to optimize creation and management of inventory buffer levels via machine learning. In several embodiments, optimizing inventory buffer levels may lead to minimizing costs while maximizing the availability and timeliness of product deliveries. In multiple embodiments, the disclosed system may utilize supply chain data and performance monitoring with automated machine learning and derivation of demand signatures and profiles to provide optimized creation and management of inventory buffer levels.