An augmented reality (AR) subsystem including one or more machine learning models, automatically overlays an augmented reality image, e.g., a border or outline, that identifies cells of potential interest, in the field of view of the specimen as seen through the eyepiece of an LCM microscope. The operator does not have to manually identify the cells of interest for subsequent LCM, e.g, on a workstation monitor, as in the prior art. The operator is provided with a switch, operator interface tool or other mechanism to select the identification of the cells, that is, indicate approval of the identification of the cells, while they view the specimen through the eyepiece. Activation of the switch or other mechanism invokes laser excising and capture of the cells of interest via a known and conventional LCM subsystem.