- 专利标题： PREFUSION PIV F IMMUNOGENS AND THEIR USE
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申请号： US17378587申请日： 2021-07-16
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公开(公告)号： US20220024987A1公开(公告)日： 2022-01-27
- 发明人: Baoshan Zhang , Guillaume Stewart-Jones , John Mascola , Kai Xu , Gwo-Yu Chuang , Li Ou , Peter Kwong , Yaroslav Tsybovsky , Wing-Pui Kong , Aliaksandr Druz , Davide Corti , Antonio Lanzavecchia
- 申请人： The United States of America, as represented by the Secretary, Department of Health and Human , Institute for Research in Biomedicine
- 申请人地址： US MD Bethesda; CH Bellinzona
- 专利权人： The United States of America, as represented by the Secretary, Department of Health and Human,Institute for Research in Biomedicine
- 当前专利权人： The United States of America, as represented by the Secretary, Department of Health and Human,Institute for Research in Biomedicine
- 当前专利权人地址： US MD Bethesda; CH Bellinzona
- 主分类号： C07K14/005
- IPC分类号： C07K14/005 ; A61K39/155 ; A61P31/14 ; C12N7/00
摘要：
Embodiments of a recombinant human Parainfluenza Virus (hPIV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the hPIV F ectodomain trimer and methods of producing the hPIV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or inhibiting a hPIV infection in a subject by administering a effective amount of the recombinant hPIV F ectodomain trimer to the subject.
公开/授权文献
- US11845778B2 Prefusion PIV F immunogens and their use 公开/授权日：2023-12-19
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