A communication device includes an antenna configured to receive a signal in a receive band and transmit a signal in a transmit band through a duplexer, analog transmitter-side radio frequency (RF) self-interference cancelation (SIC) circuitry configured to reduce power of the transmit signal in the receive band before input to the antenna, analog receiver-side RF SIC circuitry configured to reduce power of the receive signal in the transmit band before input to a first analog-to-digital converter (ADC) to convert the receive signal from analog to digital, a coupler configured to couple a small part of the transmit signal to a second ADC to convert the transmit signal from analog to digital, and digital SIC circuitry configured to process the digital sample to generate and apply an SIC signal to the digital receive signal to cancel interference induced in the receive signal by the transmit signal.