A distal aspiration catheter comprises catheter body having a central lumen and at least one luminal channel. An aspiration source is configured to attach to a proximal end/luer hub of the central lumen. Each luminal channel includes one mandrel and a distal portion of the mandrel extends into a distal portion in the central lumen. When the aspiration source is activated, a clot/emboli lodged in a blood vessel is partially ingested into the distal portion of the central lumen. The distal portion of the mandrel can move into the partially ingested clot to induce clot fatigue. The fatigued clot can be removed completely by a single pass of the distal aspiration catheter.