- 专利标题： OXAZOLIDINONE COMPOUNDS AND METHODS OF USE THEREOF AS ANTIBACTERIAL AGENTS
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申请号： US17422308申请日： 2019-12-19
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公开(公告)号： US20220081403A1公开(公告)日： 2022-03-17
- 发明人: Randall R. Miller , Joseph A. Kozlowski , Philippe Nantermet , David B. Olsen , Jing Su , Lihu Yang , Takao Suzuki , Brendan Crowley , Negxue Wang , Lanying You
- 申请人： Randall R. MILLER , Joseph A. KOZLOWSKI , Philippe NANTERMET , David B. OLSEN , Jing SU , Uihu YANG , Takao SUZUKI , Brendan M. CROWLEY , Nengxue WANG , Lanying YOU , Merck Sharp & Dohme Corp.
- 申请人地址： US Kenilworth Site; US NJ Princeton; US West Point Site; US West Point Site; US Kenilworth Site; US NJ Edison; CN Shanghai; US West Point Site; CN Shanghai; CN Shanghai; US NJ Rahway
- 专利权人： Randall R. MILLER,Joseph A. KOZLOWSKI,Philippe NANTERMET,David B. OLSEN,Jing SU,Uihu YANG,Takao SUZUKI,Brendan M. CROWLEY,Nengxue WANG,Lanying YOU,Merck Sharp & Dohme Corp.
- 当前专利权人： Randall R. MILLER,Joseph A. KOZLOWSKI,Philippe NANTERMET,David B. OLSEN,Jing SU,Uihu YANG,Takao SUZUKI,Brendan M. CROWLEY,Nengxue WANG,Lanying YOU,Merck Sharp & Dohme Corp.
- 当前专利权人地址： US Kenilworth Site; US NJ Princeton; US West Point Site; US West Point Site; US Kenilworth Site; US NJ Edison; CN Shanghai; US West Point Site; CN Shanghai; CN Shanghai; US NJ Rahway
- 国际申请： PCT/CN2019/126641 WO 20191219
- 主分类号： C07D263/06
- IPC分类号： C07D263/06 ; C07D471/04 ; C07D413/12 ; C07D495/04 ; C07F9/653 ; C07F9/6553 ; A61K31/422 ; A61K31/421 ; A61K31/437 ; A61K31/498 ; A61K31/4439 ; A61K31/541 ; A61P31/06 ; A61K45/06
摘要：
The present invention discloses oxazolidinone compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A and E, are as defined herein. The present invention also relates to compositions which comprise at least one oxazolidinone compound of the invention. The invention also provides methods for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial infections by Mycobacterium tuberculosis comprising administering a therapeutically effective amount of an oxazolidinone of the invention and/or a pharmaceutically acceptable salt thereof, or a composition comprising such compound and/or salt.
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