公开(公告)号：US20180016263A1

公开(公告)日：2018-01-18

申请号：US15545891

申请日：2016-02-08

申请人： Alexander PASTERNAK ,  Jessica FRIE ,  Shuzhi DONG ,  Takao SUZUKI ,  Shouning XU ,  Merck Sharp & Dohme Corp.

发明人： Alexander Pasternak ,  Jessica Frie ,  Shuzhi Dong ,  Takao Suzuki ,  Shouning Xu

IPC分类号： C07D405/14 ,  A61K31/496 ,  C07D413/14

CPC分类号： C07D405/14 ,  A61K31/496 ,  A61K2300/00 ,  A61P9/00 ,  C07D413/14

摘要： The present invention provides compounds of Formula (I); and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.

公开(公告)号：US09871933B2

公开(公告)日：2018-01-16

申请号：US15370061

申请日：2016-12-06

申请人： Hiroshi Suzuki ,  Takao Suzuki

发明人： Hiroshi Suzuki ,  Takao Suzuki

IPC分类号： H04N1/00 ,  G06F3/12 ,  G06K15/02

CPC分类号： H04N1/0044 ,  G06F3/1208 ,  G06F3/1256 ,  G06F3/1294 ,  G06K15/1813 ,  G06K15/1822 ,  H04N1/00204 ,  H04N1/00344 ,  H04N2201/0039 ,  H04N2201/0094

摘要： An information processing apparatus is for generating image data by using drawing information for drawing an image. The information processing apparatus includes a print data acquirer configured to acquire print data including the drawing information from outside; a request acceptor configured to accept a request to display the image data of any page in the print data; a reader configured to read specific drawing information of pages in the print data up to a page before the any page accepted by the request acceptor, from a drawing information storage storing the specific drawing information, which is the drawing information that may be applied to the image data of pages after a page in which the drawing information is described, among the drawing information included in the print data; and a generator configured to generate the image data of the any page by applying the read specific drawing information.

公开(公告)号：US09850245B2

公开(公告)日：2017-12-26

申请号：US15505277

申请日：2015-10-26

申请人： Merck Sharp & Dohme Corp. ,  Alexander Pasternak ,  Fa-Xiang Ding ,  Shuzhi Dong ,  Jinlong Jiang ,  Haifeng Tang ,  Xin Gu ,  Reynalda K. DeJesus ,  Jessica Frie ,  Qinghong Fu ,  Takao Suzuki ,  Zhifa Pu

发明人： Alexander Pasternak ,  Fa-Xiang Ding ,  Shuzhi Dong ,  Jinlong Jiang ,  Haifeng Tang ,  Xin Gu ,  Reynalda K. DeJesus ,  Jessica Frie ,  Qinghong Fu ,  Takao Suzuki ,  Zhifa Pu

IPC分类号： C07D471/10 ,  A61K31/499 ,  C07D498/10 ,  A61K31/5386 ,  A61K31/55 ,  A61K31/435 ,  A61K31/537 ,  C07D498/20 ,  A61K31/553 ,  A61K45/06

CPC分类号： C07D471/10 ,  A61K31/401 ,  A61K31/41 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/435 ,  A61K31/4422 ,  A61K31/499 ,  A61K31/537 ,  A61K31/5386 ,  A61K31/55 ,  A61K31/553 ,  A61K45/06 ,  C07D487/10 ,  C07D498/10 ,  C07D498/20 ,  A61K2300/00

摘要： The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.

公开(公告)号：US09708579B2

公开(公告)日：2017-07-18

申请号：US11915678

申请日：2006-05-22

申请人： Nobuhiro Ogasawara ,  Mayumi Ishii ,  Masaki Yoshikawa ,  Tatsuyuki Kudo ,  Ryoichi Akahoshi ,  Akihisa Matsui ,  Susumu Mizusawa ,  Haruyuki Kimizuka ,  Takao Suzuki

发明人： Nobuhiro Ogasawara ,  Mayumi Ishii ,  Masaki Yoshikawa ,  Tatsuyuki Kudo ,  Ryoichi Akahoshi ,  Akihisa Matsui ,  Susumu Mizusawa ,  Haruyuki Kimizuka ,  Takao Suzuki

IPC分类号： A23C9/12 ,  C12N1/20 ,  A23L7/10 ,  A23L33/105 ,  A23L33/135

CPC分类号： C12N1/20 ,  A23L7/115 ,  A23L33/105 ,  A23L33/135 ,  A23Y2220/00

摘要： An object of the invention is to provide a lactic acid bacteria fermentation product, which has been obtained by culturing lactic acid bacteria on a medium containing an extract of at least one food material selected from the group consisting of rice bran, persimmon leaves, perilla, Houttuynia cordata Thunb, Eucommia ulmoides Oliv., turmeric, clove, cinnamon and Rubus suavissimus S. Lee (Rosaceae). By adding and mixing the extract used for the preparation of the fermentation product to a medium, it is possible to increase simply the viable cell count of lactic acid bacteria, without affecting the flavor of the product. It is possible, by using the extract, to obtain a lactic acid bacteria fermentation product which contains many viable lactic acid bacteria with their activities highly maintained, and further to provide beverages or foods using the product.

公开(公告)号：US09179889B2

公开(公告)日：2015-11-10

申请号：US13496832

申请日：2010-11-12

申请人： Takenori Fukumoto ,  Akihiro Kawabata ,  Makiko Urabe ,  Takao Suzuki ,  Yushi Nishimura

发明人： Takenori Fukumoto ,  Akihiro Kawabata ,  Makiko Urabe ,  Takao Suzuki ,  Yushi Nishimura

IPC分类号： A61B8/02 ,  A61B8/08

CPC分类号： A61B8/0858 ,  A61B8/0891 ,  A61B8/5284

摘要： An ultrasonic diagnostic apparatus according to the present invention includes: an ultrasonic signal processing section, which performs transmission processing for transmitting an ultrasonic wave toward a subject's blood vessel by driving a probe and reception processing for generating a received signal based on the ultrasonic wave reflected from the subject's blood vessel and received at the probe; a tomographic image processing section, which generates a tomographic image based on the received signal; a boundary detecting section, which detects the lumen-intima and media-adventitia boundaries of the blood vessel based on the received signal or the tomographic image; a vascular wall thickness calculating section, which calculates, as a vascular wall thickness value, the interval between the lumen-intima and media-adventitia boundaries detected by the boundary detecting section; a reliability determining section, which determines the reliability of the vascular wall thickness value by a signal feature of the received signal or an image information feature of the tomographic image at a location on the lumen-intima and/or media-adventitia boundaries detected; and a control section, which decides, in accordance with the decision made by the reliability determining section, that the vascular wall thickness value be defined as an intima-media thickness.

摘要翻译： 根据本发明的超声波诊断装置包括：超声波信号处理部，其进行用于通过驱动探头向被检者的血管发送超声波的发送处理和基于从所述超声波反射的超声波生成接收信号的接收处理 受试者的血管并在探头处接受; 断层图像处理部，其基于所接收的信号生成断层图像; 边界检测部，其基于所接收的信号或断层图像检测血管的内腔和介质 - 外膜边界; 血管壁厚计算部，其计算由所述边界检测部检测出的所述内腔和介质 - 外膜边界之间的间隔作为血管壁厚度值; 可靠性确定部，其通过接收信号的信号特征或者在检测到的管腔内膜和/或介质外膜边界上的位置处的断层图像的图像信息特征来确定血管壁厚值的可靠性; 以及控制部，其根据所述可靠性判定部的判定，判断为血管壁厚值被定义为内膜中间厚度。

公开(公告)号：US08835520B2

公开(公告)日：2014-09-16

申请号：US13498668

申请日：2009-09-30

申请人： Shunji Hyoudou ,  Kouichi Adachi ,  Takao Suzuki ,  Kentarou Nezu

发明人： Shunji Hyoudou ,  Kouichi Adachi ,  Takao Suzuki ,  Kentarou Nezu

IPC分类号： C08J9/228 ,  C08J9/02 ,  C08J9/10

CPC分类号： C08J9/02 ,  C08J9/10 ,  C08J2201/026 ,  C08J2205/052 ,  C08J2309/02 ,  C08L9/02

摘要： The present invention provides a rubber-based resin closed-cell foam sheet with its sealing capability being unlikely to be lowered even for a prolonged period of use, and with its excellent waterproofing capability. The inventive rubber-based resin closed-cell foam sheet is characterized in that the foam sheet includes a rubber-based resin containing a nitrile group, and exhibits an excellent adhesion. When used as a waterproof sealing material, the foam sheet can adhere, in a tightly close contact, to the interface of a portion to be sealed. Therefore, the inventive rubber-based resin closed-cell foam sheet can be advantageously used as a waterproof sealing material having high sealing capability and excellent waterproofing capability.

摘要翻译： 本发明提供一种即使长时间使用也不会降低其密封性的橡胶类树脂闭孔发泡体片，并且具有优异的防水性能。 本发明的橡胶类树脂闭孔泡沫片的特征在于，发泡片包括含有腈基的橡胶系树脂，粘合性优异。 当用作防水密封材料时，泡沫片可以紧密接触地粘合到待密封部分的界面上。 因此，本发明的橡胶类树脂闭孔发泡体片材可以有利地用作具有高密封能力和优异的防水能力的防水密封材料。

公开(公告)号：US20130304382A1

公开(公告)日：2013-11-14

申请号：US13991772

申请日：2011-12-05

申请人： Hirokazu Nomoto ,  Ichiro Usami ,  Kensuke Hanaoka ,  Sayaka Yoshizu ,  Hironobu Sugimoto ,  Takao Suzuki ,  Hiroshi Takeuchi ,  Shohji Ueoka ,  Hideaki Miyazaki ,  Toshifumi Obayashi ,  Takayuki Suzumiya

发明人： Hirokazu Nomoto ,  Ichiro Usami ,  Kensuke Hanaoka ,  Sayaka Yoshizu ,  Hironobu Sugimoto ,  Takao Suzuki ,  Hiroshi Takeuchi ,  Shohji Ueoka ,  Hideaki Miyazaki ,  Toshifumi Obayashi ,  Takayuki Suzumiya

IPC分类号： G01C21/34

CPC分类号： G01C21/34 ,  G01C21/26 ,  G01C21/3415 ,  G01C21/3626 ,  G01C21/3655

摘要： Navigation systems, methods, and programs acquire deviated point information regarding a deviated point where a vehicle traveling a set route has deviated the route, and acquire post-deviation travel history information regarding a travel history after a deviated vehicle has deviated the route at the deviated point. The systems, methods, and programs determine based on the post-deviation travel history information for each of the deviated vehicles whether the deviated vehicle has traveled along a reroute set after deviating the route at the deviated point, and judges whether a rate of the deviated vehicles which were determined as having traveled along the reroute is a first predetermined value or more. If the rate of the deviated vehicles which were determined as having traveled along the reroute is the first predetermined value or more, the systems, methods, and programs determine that guidance of the route is not appropriate.

摘要翻译： 导航系统，方法和程序获取关于车辆行驶设定路线偏离路线的偏离点的偏离点信息，并且在偏离的车辆偏离了偏离的路线之后获取关于行驶历史的偏离后行驶历史信息 点。 系统，方法和程序基于每个偏差车辆的偏离后旅行历史信息来确定偏差车辆是否在偏离路线之后沿着重路由组行驶，并且判断偏差车辆的速率 被确定为沿着路线行驶的车辆是第一预定值或更多。 如果被确定为沿路线行驶的偏差车辆的速率是第一预定值或更多，则系统，方法和程序确定路线的引导是不合适的。

公开(公告)号：US20130209412A1

公开(公告)日：2013-08-15

申请号：US13877238

申请日：2011-09-27

申请人： Ryotaro Hoshi ,  Hiroe Utsumi ,  Akihisa Matsui ,  Takao Suzuki

发明人： Ryotaro Hoshi ,  Hiroe Utsumi ,  Akihisa Matsui ,  Takao Suzuki

IPC分类号： A23C9/12 ,  A61K35/74

CPC分类号： A23C9/1203 ,  A23C9/1234 ,  A23C9/1307 ,  A23L33/105 ,  A23Y2300/00 ,  A23Y2300/29 ,  A61K35/745

摘要： The purpose of the present invention is to provide a technique whereby the flavor of products such as fermented milk that use the Bifidobacterium bacteria can be improved while maintaining the effect of the Rubus suavissimus S. Lee for improving the viability of the Bifidobacterium bacteria. Provided is a fermented food that includes: a Rubus suavissimus S. Lee essence obtained as a concentrate through electrodialyzing a Rubus suavissimus S. Lee extract added with an inorganic salt; and bacteria of the genus Bifidobacterium. Also provided is a method for producing such fermented foods.

摘要翻译： 本发明的目的是提供一种可以改善使用双歧杆菌细菌的发酵乳等产品的风味，同时保持Rubus suavissimus S.Lee的作用以改善双歧杆菌细菌的生存力的技术。 提供了一种发酵食品，其包括：通过电渗析加入无机盐的Rubus suavissimus S.Le提取物作为浓缩物获得的Rubus suavissimus S.Lite精华; 和双歧杆菌属的细菌。 还提供了这样的发酵食品的制造方法。

公开(公告)号：US08493686B2

公开(公告)日：2013-07-23

申请号：US12787322

申请日：2010-05-25

申请人： Shinichi Kimura ,  Hiroki Kitahori ,  Nobuyuki Okunaga ,  Takao Suzuki

发明人： Shinichi Kimura ,  Hiroki Kitahori ,  Nobuyuki Okunaga ,  Takao Suzuki

IPC分类号： G11B33/12

CPC分类号： G06F1/1658 ,  G11B25/043

摘要： A disk-enclosure cover for a low-profile, hard-disk drive (HDD). The disk-enclosure cover includes a substantially flat, plate-like portion that includes a periphery, and a peripheral flange that is disposed at the periphery. The peripheral flange includes a recessed portion that is configured to be recessed from a SATA connector in proximity to the SATA connector. In addition, the recessed portion is configured to allow a top portion of the SATA connector to be disposed in close proximity to the peripheral flange when the SATA connector is seated on a receiving connector of the low-profile HDD.

摘要翻译： 用于低调硬盘驱动器（HDD）的磁盘机箱盖。 盘封闭盖包括一个基本上平坦的板状部分，其包括一个周边，以及设置在周边的周边凸缘。 周边凸缘包括凹陷部分，其被配置为从SATA连接器在SATA连接器附近凹进。 此外，当SATA连接器安置在低调硬盘的接收连接器上时，凹部被配置为允许SATA连接器的顶部靠近周边凸缘设置。

公开(公告)号：US20120232179A1

公开(公告)日：2012-09-13

申请号：US13498668

申请日：2009-09-30

申请人： Shunji Hyoudou ,  Kouichi Adachi ,  Takao Suzuki ,  Kentarou Nezu ,  Mao Nezu

发明人： Shunji Hyoudou ,  Kouichi Adachi ,  Takao Suzuki ,  Kentarou Nezu ,  Mao Nezu

IPC分类号： C08L9/02 ,  C08J9/228

CPC分类号： C08J9/02 ,  C08J9/10 ,  C08J2201/026 ,  C08J2205/052 ,  C08J2309/02 ,  C08L9/02

摘要： The present invention provides a rubber-based resin closed-cell foam sheet with its sealing capability being unlikely to be lowered even for a prolonged period of use, and with its excellent waterproofing capability. The inventive rubber-based resin closed-cell foam sheet is characterized in that the foam sheet includes a rubber-based resin containing a nitrile group, and exhibits an excellent adhesion. When used as a waterproof sealing material, the foam sheet can adhere, in a tightly close contact, to the interface of a portion to be sealed. Therefore, the inventive rubber-based resin closed-cell foam sheet can be advantageously used as a waterproof sealing material having high sealing capability and excellent waterproofing capability.

摘要翻译： 本发明提供一种即使长时间使用也不会降低其密封性的橡胶类树脂闭孔发泡体片，并且具有优异的防水性能。 本发明的橡胶类树脂闭孔泡沫片的特征在于，发泡片包括含有腈基的橡胶系树脂，粘合性优异。 当用作防水密封材料时，泡沫片可以紧密接触地粘合到待密封部分的界面上。 因此，本发明的橡胶类树脂闭孔发泡体片材可以有利地用作具有高密封能力和优异的防水能力的防水密封材料。