This manufacturing method of a grain-oriented electrical steel sheet is a manufacturing method of a grain-oriented electrical steel sheet having no forsterite film, in which in a decarburization annealing process, a cold-rolled steel sheet is (i-1) heated at an average heating rate (HR1) of 40 to 500° C./sec in a temperature range of 550° C. or higher and lower than 720° C., (i-2) heated at an average heating rate (HR2), which is 5 to 50° C./sec, in a temperature range of 720° C. to T1° C. (770° C.≤T1 (° C.)≤900° C.), and (ii) retained at the temperature of T1° C. for 50 to 1000 seconds to make an amount of C 25 ppm or less in an atmosphere of an oxygen partial pressure (P1) which is 0.0010 to 0.20.