- 专利标题： HEPATITIS C VIRUS IMMUNOGENIC COMPOSITIONS AND METHODS OF USE THEREOF
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申请号： US17511177申请日： 2021-10-26
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公开(公告)号： US20220105175A1公开(公告)日： 2022-04-07
- 发明人: Michael Houghton , Abdolamir Landi , Michael Logan , John L. Law , Darren Hockman , Chao Chen
- 申请人： The Governors of the University of Alberta
- 申请人地址： CA Edmonton
- 专利权人： The Governors of the University of Alberta
- 当前专利权人： The Governors of the University of Alberta
- 当前专利权人地址： CA Edmonton
- 主分类号： A61K39/29
- IPC分类号： A61K39/29 ; A61K39/12
摘要：
The present disclosure provides an immunogenic composition comprising: a) a hepatitis C virus (HCV) heterodimeric polypeptide that includes HCV E1 and E2 polypeptides; b) a T-cell epitope polypeptide comprising a T-cell epitope present in an HCV protein other than E1 and E2; and c) a pharmaceutically acceptable excipient. The present disclosure provides a method of inducing an immune response, in an individual, to an HCV polypeptide. The present disclosure provides an immunogenic composition comprising: a) a polypeptide that comprises one or more T-cell epitopes present in an HCV protein other than E1 and E2; and b) a pharmaceutically acceptable excipient.
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