A handrail disinfection system for vehicle with handrail is mounted on a vehicle having handrail for grasping by an occupant. The handrail disinfection system includes a tank to store disinfectant solution, an exudation part provided on the handrail, an actuator for exuding the disinfectant solution stored in the tank from the exudation part, and a controller for controlling the actuator. At least one processor included in the controller executes upon execution of at least one program, performing a disinfecting process in which the actuator is controlled to exude the disinfectant solution from the exudation part to a surface of the handrail when a predetermined execution condition is satisfied.