- 专利标题： KETOAMIDE COMPOUND AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND USE THEREOF
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申请号： US17267375申请日： 2019-08-09
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公开(公告)号： US20220112177A1公开(公告)日： 2022-04-14
- 发明人: Hong Liu , Shibo Jiang , Wenhao Dai , Lu Lu , Jingjing Peng , Shuai Xia , Jiang Wang , Jian Li , Hualiang Jiang , Kaixian Chen
- 申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Fudan University
- 申请人地址： CN Shanghai; CN Shanghai
- 专利权人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences,Fudan University
- 当前专利权人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences,Fudan University
- 当前专利权人地址： CN Shanghai; CN Shanghai
- 优先权： CN201810903062.1 20180809
- 国际申请： PCT/CN2019/100060 WO 20190809
- 主分类号： C07D403/12
- IPC分类号： C07D403/12 ; C07D401/12 ; C07D405/12 ; C07D409/12 ; C07D209/20 ; C07D241/44 ; C07D413/12 ; A61P31/12 ; C07D471/04
摘要：
A ketoamide compound and a preparation method, a pharmaceutical composition, and a use thereof. Specifically, the ketoamide compound shown in formula (A), a racemate, an enantiomer, or a diastereoisomer thereof, or any mixture of same, or a pharmaceutically active metabolite thereof, or a pharmaceutically acceptable salt, solvate, or prodrug thereof. The ketoamide compound can effectively inhibit coronavirus or Ebola virus, and thereby implement the prevention or treatment of diseases related to coronavirus or diseases related to Ebola virus.
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