公开(公告)号：US20220112177A1

公开(公告)日：2022-04-14

申请号：US17267375

申请日：2019-08-09

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences ,  Fudan University

发明人： Hong Liu ,  Shibo Jiang ,  Wenhao Dai ,  Lu Lu ,  Jingjing Peng ,  Shuai Xia ,  Jiang Wang ,  Jian Li ,  Hualiang Jiang ,  Kaixian Chen

IPC分类号： C07D403/12 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D209/20 ,  C07D241/44 ,  C07D413/12 ,  A61P31/12 ,  C07D471/04

摘要： A ketoamide compound and a preparation method, a pharmaceutical composition, and a use thereof. Specifically, the ketoamide compound shown in formula (A), a racemate, an enantiomer, or a diastereoisomer thereof, or any mixture of same, or a pharmaceutically active metabolite thereof, or a pharmaceutically acceptable salt, solvate, or prodrug thereof. The ketoamide compound can effectively inhibit coronavirus or Ebola virus, and thereby implement the prevention or treatment of diseases related to coronavirus or diseases related to Ebola virus.

公开(公告)号：US11999806B2

公开(公告)日：2024-06-04

申请号：US16963196

申请日：2019-01-21

申请人： WUHAN INSTITUTE OF VIROLOGY, CHINESE ACADEMY OF SCIENCES ,  FUDAN UNIVERSITY

发明人： Xi Zhou ,  Lu Lu ,  Yuan Fang ,  Shibo Jiang ,  Zezhong Liu ,  Chengfeng Qin ,  Yang Qiu ,  Jingfang Mu

IPC分类号： A61K38/00 ,  A61P31/14 ,  C07K7/08

CPC分类号： C07K7/08 ,  A61P31/14 ,  A61K38/00

摘要： Provided are a series of polypeptides with antiviral activity. The present invention provides a new strategy for preventing and controlling Enterovirus such as EV71, CVA16, CVA6, CVB3, and CVB5 viruses and provides a new theoretical basis for accelerating the research and development of a polypeptide small molecule drug against Enterovirus such as EV71, CVA16, CVA6, CVB3, and CVB5 viruses.