Methods and systems are provided for heat sanitizing a vehicle. In one example, a method may include, while receiving power from an external power source and responsive to receiving a request for cleaning an interior of a vehicle, operating an electric heater of a heating, ventilation, and air-conditioning (HVAC) system to heat the interior above an upper threshold temperature for a first threshold duration using the power received from the external power source. In this way, the HVAC system may be advantageously used to expose the vehicle interior to temperatures that kill or inactive microbes while vehicle battery power and fuel are conserved by using power supplied from the external power source.