- 专利标题： 2-AMINO-N-PHENYL-NICOTINAMIDES AS NAV1.8 INHIBITORS
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申请号： US17289152申请日： 2019-10-28
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公开(公告)号： US20220119363A1公开(公告)日： 2022-04-21
- 发明人: Michael J. Breslin , Christopher James Bungard , Harry R. Chobanian , Kristen L. G. Jones , Mark E. Layton , Jian Liu , James J. Perkins , Jeffrey William Schubert , Shawn J. Stachel , Linda M. Suen-Lai , Zhe Wu
- 申请人： Merck Sharp & Dohme Corp.
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 国际申请： PCT/US19/58251 WO 20191028
- 主分类号： C07D401/04
- IPC分类号： C07D401/04 ; C07D213/82 ; C07D401/14 ; C07D487/18 ; C07D498/08 ; C07D513/04 ; C07D413/04 ; C07D417/04 ; C07D487/08 ; C07D491/107 ; C07D498/04 ; C07D491/048 ; C07D417/14 ; C07D409/14 ; C07D405/14 ; C07D403/04 ; C07D451/02
摘要：
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Nav1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Nav1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.