A manufacturing machine and method for the production of a cartridge for an electronic cigarette can include at least one movable plate, where at least one first seat is present, which is designed to house a support of a heating device, and at least one second seat, which is axially aligned with the first seat and is designed to house a mouthpiece; an assembling conveyor to cyclically move the movable plate along an annular assembling path; a first feeding station arranged along the assembling path, in which a support of a heating device is fed into the first seat; a second feeding station arranged along the assembling path, in which a mouthpiece is fed into the second seat; and a transfer station, in which a support of a heating device and a mouthpiece are simultaneously removed from the movable plate.