Methods and systems for securing a medical implant at a valve. An illustrative method may include advancing a delivery system though a vasculature to a target location. At the target location, the delivery system may be proximally retracted to expose a medical implant carried within a lumen of the delivery system. The medical implant may be radially expanded from a collapsed delivery configuration an expanded deployed configuration. A fixation mechanism delivery system may be advanced through the vasculature to the target location. A first fixation mechanism configured to engage a native tissue and a portion of the medical implant may be deployed from the fixation mechanism delivery system. After deploying the fixation mechanism, the medical implant may be released from the delivery system.