Invention Application
- Patent Title: RNA CANCER VACCINES
-
Application No.: US17291947Application Date: 2019-11-07
-
Publication No.: US20220125899A1Publication Date: 2022-04-28
- Inventor: Ted Ashburn , Kristen Hopson , Karen Keating , Joseph Senn , Christine Swenson , Benjamin Breton , Shan Zhong , Maija Garnaas
- Applicant: ModernaTX, Inc.
- Applicant Address: US MA Cambridge
- Assignee: ModernaTX, Inc.
- Current Assignee: ModernaTX, Inc.
- Current Assignee Address: US MA Cambridge
- International Application: PCT/US2019/060208 WO 20191107
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/395 ; A61K9/51 ; A61K31/7105 ; A61K48/00 ; A61P35/00 ; C07K16/28

Abstract:
The present application is related to a method of treating a cancer by administering to a human subject multiple doses of a mRNA cancer vaccine formulated as a lipid nanoparticle wherein the cancer vaccine comprises one or more mRNAs each having one or more open reading frames encoding 3-50 peptide epitopes, and wherein each of the peptide epitopes are portions of personalized cancer antigens or portions of cancer hotspot antigens. The present application further relates to a method of treating cancer by combining anti-cancer immunotherapy with the administration of the aforementioned mRNA cancer vaccine.
Information query