公开(公告)号：US20220125899A1

公开(公告)日：2022-04-28

申请号：US17291947

申请日：2019-11-07

Applicant: ModernaTX, Inc.

Inventor： Ted Ashburn ,  Kristen Hopson ,  Karen Keating ,  Joseph Senn ,  Christine Swenson ,  Benjamin Breton ,  Shan Zhong ,  Maija Garnaas

IPC: A61K39/00 ,  A61K39/395 ,  A61K9/51 ,  A61K31/7105 ,  A61K48/00 ,  A61P35/00 ,  C07K16/28

Abstract: The present application is related to a method of treating a cancer by administering to a human subject multiple doses of a mRNA cancer vaccine formulated as a lipid nanoparticle wherein the cancer vaccine comprises one or more mRNAs each having one or more open reading frames encoding 3-50 peptide epitopes, and wherein each of the peptide epitopes are portions of personalized cancer antigens or portions of cancer hotspot antigens. The present application further relates to a method of treating cancer by combining anti-cancer immunotherapy with the administration of the aforementioned mRNA cancer vaccine.