Invention Application
- Patent Title: 5'-MODIFIED NUCLEOSIDE AND NUCLEOTIDE USING SAME
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Application No.: US17428998Application Date: 2020-02-10
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Publication No.: US20220127300A1Publication Date: 2022-04-28
- Inventor: Satoshi OBIKA , Takao YAMAGUCHI , Takaki HABUCHI , Go KATO , Takao INOUE , Tokuyuki YOSHIDA , Md Ariful ISLAM
- Applicant: Osaka University
- Applicant Address: JP Osaka
- Assignee: Osaka University
- Current Assignee: Osaka University
- Current Assignee Address: JP Osaka
- Priority: JP2019-023514 20190213
- International Application: PCT/JP2020/005095 WO 20200210
- Main IPC: C07H21/04
- IPC: C07H21/04
Abstract:
Disclosed are a 5′-modified nucleoside and a nucleotide using the same. The nucleoside of the present invention is represented by the formula (I) below. The 5′-modified nucleoside of the present invention is usable as a substitute for a phosphorothioate-modified nucleic acid, which has a risk of, for example, accumulation in a specific organ. The 5′-modified nucleoside also has excellent industrial productivity because a diastereomer separation step is not involved in the production process thereof.
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