公开(公告)号：US20220372060A1

公开(公告)日：2022-11-24

申请号：US17427134

申请日：2020-01-31

Applicant: Osaka University

Inventor： Satoshi OBIKA ,  Takao YAMAGUCHI ,  Takaki HABUCHI ,  Go KATO ,  Takao INOUE ,  Tokuyuki YOSHIDA ,  Takaya SUGIURA

IPC: C07H19/10 ,  C07H19/20 ,  C07H21/00

Abstract: Disclosed are a 5′-modified nucleoside and a nucleotide using the same. The nucleoside of the present invention is represented by the formula (I) below. The 5′-modified nucleoside of the present invention is usable as a substitute for a phosphorothioate-modified nucleic acid, which has a risk of, for example, accumulation in a specific organ. The 5′-modified nucleoside also has excellent industrial productivity because a diastereomer separation step is not involved in the production process thereof.

公开(公告)号：US20220127300A1

公开(公告)日：2022-04-28

申请号：US17428998

申请日：2020-02-10

Applicant: Osaka University

Inventor： Satoshi OBIKA ,  Takao YAMAGUCHI ,  Takaki HABUCHI ,  Go KATO ,  Takao INOUE ,  Tokuyuki YOSHIDA ,  Md Ariful ISLAM

IPC: C07H21/04

Abstract: Disclosed are a 5′-modified nucleoside and a nucleotide using the same. The nucleoside of the present invention is represented by the formula (I) below. The 5′-modified nucleoside of the present invention is usable as a substitute for a phosphorothioate-modified nucleic acid, which has a risk of, for example, accumulation in a specific organ. The 5′-modified nucleoside also has excellent industrial productivity because a diastereomer separation step is not involved in the production process thereof.