A system includes a container configured to hold one or more items contaminated with a contaminant. The system also includes a power amplifier configured to output radio frequency (RF) energy at a frequency substantially equal to a resonant frequency of the contaminant. The system further includes a horn connected to the power amplifier and configured to propagate the RF energy along a length of the container and through the one or more items to deactivate, damage, or destroy the contaminant by molecular resonance. In addition, the system includes an RF absorbing liner disposed on interior surfaces of the container and configured to absorb and reduce reflection of at least some of the RF energy.