Invention Application
- Patent Title: GIP RECEPTOR AGONIST PEPTIDE COMPOUNDS AND USES THEREOF
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Application No.: US17279266Application Date: 2019-09-24
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Publication No.: US20220135638A1Publication Date: 2022-05-05
- Inventor: Hiroshi IMOTO , Mari ADACHI , Yoko KANEMATSU , Taiji ASAMI , Ayumu NIIDA , Naoki NISHIZAWA , Derek Cecil COLE , Mack FLINSPACH , Nick SCORAH , Abhijit Suresh BHAT
- Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
- Applicant Address: JP Osaka-shi, Osaka
- Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED
- Current Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED
- Current Assignee Address: JP Osaka-shi, Osaka
- International Application: PCT/JP2019/038441 WO 20190924
- Main IPC: C07K14/575
- IPC: C07K14/575 ; A61K9/00 ; A61K9/08 ; A61K47/02 ; A61K9/20 ; A61P1/08

Abstract:
The present disclosure provides GIP receptor agonist peptide compounds having an activating action on GIP receptors and use of the GIP receptor agonist peptide as a medicament for the treatment and/or prevention of diabetes, obesity, emesis, or a symptom or condition associated with diabetes, obesity, or emesis. Specifically, a GIP receptor agonist peptide containing a sequence represented by the formula (I) or a salt thereof, and a medicament comprising the same are provided. Formula I: P1-A1-A2-A3-A4-A5-A6-A7-A8-A9-A10-A11-A12-A13-A14-A15-A16-A17-A18-A19-A20-A21-A22-A23-A24-A25-A26-A27-A28-A29-A30-A341-A32-A33-A34-A35-A36-A37-A38-A39-A40-A41-P2 (SEQ ID NO: 4), or a salt thereof, wherein each symbol is as defined herein, with the proviso that the GIP receptor agonist peptide does not have an amino acid sequence as provided in SEQ ID NOs: 4-569 disclosed in PCT/JP2018/013540.
Public/Granted literature
- US12122815B2 GIP receptor agonist peptide compounds and uses thereof Public/Granted day:2024-10-22
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