The present disclosure belongs to the technical field of casting equipment, and provides a method and system for adjusting process parameters of a die-casting machine, and a storage medium. The method and the system can receive die wheel type, molten aluminum temperature, interruption time and defect information in real time, respond to the above information one by one according to a set response priority order, select die-casting process parameters, and automatically adjust different process parameters for different products and different working conditions, thereby realizing simultaneous control of multiple die-casting machines, replacing manual adjustment and improving product quality stability and production efficiency.