Systems and methods related to priority-based and performance-based selection of a render mode, such as a two-level binning mode, in which to execute workloads with a graphics processing unit (GPU) of a system are provided. A user mode driver (UMD) or kernel mode driver (KMD) executed at a central processing unit (CPU) configures low and medium priority workloads to be executed in a two-level binning mode and selects a binning mode for high priority workloads based on whether performance heuristics indicate that one or more binning conditions or override conditions have been met. High priority workloads are maintained in a high priority queue, while low and medium priority workloads are maintained in a low/medium priority queue, such that execution of low and medium priority workloads at the GPU can be preempted in favor of executing high priority workloads.