Interference mitigation of aerial devices is facilitated on a radio access network. An example method includes receiving, by a processor from a base station of the radio access network, an indication of an interference event associated with the base station, and determining, by the processor, a set of unmanned aerial vehicles (UAVs) associated with the base station during flight of the set, where the interference event is at least partially attributed to each UAV of the set. The method further includes selecting, by the processor, a UAV among the set based on a respective traffic profile associated with each UAV of the set, and providing, by the processor, an instruction to the UAV to cause an adjustment of an operation of the UAV to reduce an interference impact of the UAV on the base station.