Invention Application
- Patent Title: ESCHERICHIA COLI COMPOSITIONS AND METHODS THEREOF
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Application No.: US17672126Application Date: 2022-02-15
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Publication No.: US20220168410A1Publication Date: 2022-06-02
- Inventor: Robert G.K. Donald , Annaliesa Sybil Anderson , Laurent Oliver Chorro , Jianxin Gu , Jin-Hwan Kim , Srinivas Kodali , Jason Arnold Lotvin , Justin Keith Moran , Rosalind Pan , Avvari Krishna Prasad , Mark Edward Ruppen , Suddham Singh , Ling Chu , Scott Ellis Lomberk , Karen Kiyoko Takane , Nishith Merchant , Wei Chen
- Applicant: Pfizer Inc.
- Applicant Address: US NY New York
- Assignee: Pfizer Inc.
- Current Assignee: Pfizer Inc.
- Current Assignee Address: US NY New York
- Main IPC: A61K39/108
- IPC: A61K39/108 ; C08B37/00 ; A61P31/04 ; A61P37/04

Abstract:
In one aspect, the invention relates to an immunogenic composition comprising modified O-polysaccharide molecules derived from E. coli lipopolysaccharides and conjugates thereof. Multivalent vaccines may be prepared by combining two or more monovalent immunogenic compositions for different E. coli serotypes. In one embodiment, the modified O-polysaccharide molecules are produced by a recombinant bacterium that includes a wzz gene.
Public/Granted literature
- US12128095B2 Public/Granted day:2024-10-29
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