Invention Application
- Patent Title: Piperidinone Derivatives as MDM2 Inhibitors for the Treatment of Cancer
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Application No.: US17672660Application Date: 2022-02-15
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Publication No.: US20220169611A1Publication Date: 2022-06-02
- Inventor: Michael D. Bartberger , Ana Gonzalez Buenrostro , Hilary Plake Beck , Xiaoqi Chen , Richard Victor Connors , Jeffrey Deignan , Jason A. Dequette, I , John Eksterowicz , Benjamin Fisher , Brian M. Fox , Jiasheng Fu , Zice Fu , Felix Gonzalez Lopez De Turiso , Michael W. Gribble , Darin J. Gustin , Julie A. Heath , Xin Huang , XianYun Jiao , Michael G. Johnson , Frank Kayser , David John Kopecky , SuJen Lai , Yihong Li , Zhihong Li , Jiwen Liu , Jonathan D. Low , Brian S. Lucas , Zhihua Ma , Lawrence R. McGee , Josel McIntosh , Dustin L. McMinn , Julio C. Medina , Jeffrey Thomas Mihalic , Steven H. Olson , Yossup Rew , Philip M. Roveto , Daqing Sun , Xiaodong Wang , Yingcai Wang , Xuelei Yan , Ming Yu , Jiang Zhu
- Applicant: Amgen Inc.
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Main IPC: C07D211/76
- IPC: C07D211/76 ; C07D401/04 ; C07D401/06 ; C07D401/12 ; C07D407/04 ; C07D407/06 ; C07D409/04 ; C07D413/06 ; C07D417/06 ; C07D471/10 ; C07D498/08 ; C07D498/20 ; C07D279/02 ; C07D405/04 ; C07D417/12 ; C07D417/14 ; C07D491/08 ; C07D491/153 ; C07D221/20 ; C07D498/14 ; C07D405/12 ; C07D409/12
Abstract:
The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.
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