- 专利标题: PEPTIDE AND USE THEREOF
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申请号: US17593570申请日: 2020-02-27
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公开(公告)号: US20220175940A1公开(公告)日: 2022-06-09
- 发明人: Eisaku KONDO
- 申请人: NIIGATA UNIVERSITY
- 专利权人: NIIGATA UNIVERSITY
- 当前专利权人: NIIGATA UNIVERSITY
- 优先权: JP2019-057966 20190326
- 国际申请: PCT/JP2020/007917 WO 20200227
- 主分类号: A61K47/64
- IPC分类号: A61K47/64 ; C07K7/06 ; A61K47/36 ; A61K47/42 ; A61P35/00
摘要:
A peptide is composed of an amino acid sequence represented by general formula (I), and accumulates in cancer-associated fibroblasts. (In general formula (I), X11 is a peptide residue composed of an amino acid sequence of (a) or (b) below: (a) an amino acid sequence represented by any one of SEQ ID NOs: 1 to 4, (b) an amino acid sequence in which one or two amino acids have been deleted, substituted or added in an amino acid sequence represented by any one of SEQ ID NOs: 1 to 4; Y11 is a peptide linker composed of an amino acid residue of at least 1 but not more than 10 amino acids, wherein each amino acid residue is independently a glycine residue, a proline residue, a serine residue, a cysteine residue or a lysine residue; X12 is either a peptide residue composed of an amino acid sequence of (a) or (b) above, or a retro-inverso peptide residue thereof; and n11 represents an integer of at least 0 but not more than 9.) [Formula 1] X11—(Y11—X12)n11 (I)
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