Disclosed are various embodiments relating to an intersection of on-demand network slicing and content delivery. In one embodiment, in response to an application programming interface (API) request, a network slice is provisioned with a quality-of-service requirement in a radio-based network having a radio access network and an associated core network. Also in response to the API request, a transfer of content to a content delivery service at an edge location in the radio-based network is initiated in order to meet the quality-of-service requirement for the network slice.