- 专利标题： BISPECIFIC OR-GATE CHIMERIC ANTIGEN RECEPTOR RESPONSIVE TO CD19 AND CD20
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申请号： US17569107申请日： 2022-01-05
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公开(公告)号： US20220193136A1公开(公告)日： 2022-06-23
- 发明人: Yvonne Y. CHEN , Eugenia ZAH , Michael C. JENSEN
- 申请人： The Regents of the University of California , Seattle Children's Hospital DBA Seattle Children's Research Institute
- 申请人地址： US CA Oakland; US WA Seatlle
- 专利权人： The Regents of the University of California,Seattle Children's Hospital DBA Seattle Children's Research Institute
- 当前专利权人： The Regents of the University of California,Seattle Children's Hospital DBA Seattle Children's Research Institute
- 当前专利权人地址： US CA Oakland; US WA Seatlle
- 主分类号： A61K35/17
- IPC分类号： A61K35/17 ; C07K16/46 ; C12N5/0783 ; C07K16/28 ; C07K14/725 ; C07K14/705
摘要：
A CD19-OR-CD20 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD19-OR-CD20 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD19-OR-CD20 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either CD19 or CD20 (or both). It is a single molecule that confers two-input recognition capability upon human T cells engineered to stably express this CAR.
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