公开(公告)号：US20220193136A1

公开(公告)日：2022-06-23

申请号：US17569107

申请日：2022-01-05

申请人： The Regents of the University of California ,  Seattle Children's Hospital DBA Seattle Children's Research Institute

发明人： Yvonne Y. CHEN ,  Eugenia ZAH ,  Michael C. JENSEN

IPC分类号： A61K35/17 ,  C07K16/46 ,  C12N5/0783 ,  C07K16/28 ,  C07K14/725 ,  C07K14/705

摘要： A CD19-OR-CD20 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD19-OR-CD20 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD19-OR-CD20 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either CD19 or CD20 (or both). It is a single molecule that confers two-input recognition capability upon human T cells engineered to stably express this CAR.

公开(公告)号：US20210145880A1

公开(公告)日：2021-05-20

申请号：US17028701

申请日：2020-09-22

申请人： The Regents of the University of California ,  Seattle Children's Hospital DBA Seattle Children's Research Institute

发明人： Yvonne Y. CHEN ,  Eugenia ZAH ,  Michael C. JENSEN

IPC分类号： A61K35/17 ,  C07K16/46 ,  C12N5/0783 ,  C07K16/28 ,  C07K14/725 ,  C07K14/705

摘要： A CD19-OR-CD20 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD19-OR-CD20 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD19-OR-CD20 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either CD19 or CD20 (or both). It is a single molecule that confers two-input recognition capability upon human T cells engineered to stably express this CAR.

公开(公告)号：US20170368098A1

公开(公告)日：2017-12-28

申请号：US15535972

申请日：2015-12-14

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  SEATTLE CHILDREN'S HOSPITAL DBA SEATTLE CHILDREN'S RESEARCH INSTITUTE

发明人： Yvonne Y. CHEN ,  Eugenia ZAH ,  Michael C. JENSEN

IPC分类号： A61K35/17 ,  C07K14/725 ,  C07K16/28 ,  C12N5/0783 ,  C07K16/46 ,  C07K14/705 ,  A61K39/00 ,  A61K38/00

CPC分类号： A61K35/17 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/7051 ,  C07K14/70521 ,  C07K14/70596 ,  C07K16/2803 ,  C07K16/2887 ,  C07K16/46 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2319/03 ,  C07K2319/40 ,  C12N5/0636 ,  C12N2510/00

摘要： A CD19-OR-CD20 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD19-OR-CD20 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD19-OR-CD20 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either CD19 or CD20 (or both). It is a single molecule that confers two-input recognition capability upon human T cells engineered to stably express this CAR.

公开(公告)号：US20240075069A1

公开(公告)日：2024-03-07

申请号：US18459302

申请日：2023-08-31

申请人： ENDOCYTE, INC. ,  PURDUE RESEARCH FOUNDATION ,  SEATTLE CHILDREN'S HOSPITAL (DBA SEATTLE CHILDREN'S RESEARCH INSTITUTE)

发明人： Philip Stewart LOW ,  Haiyan CHU ,  Yingjuan June LU ,  Christopher Paul LEAMON ,  Leroy W. WHEELER, II ,  Michael C. JENSEN ,  James MATTHAEI

IPC分类号： A61K35/17 ,  A61K9/00 ,  A61K31/365 ,  A61K31/519 ,  A61K38/17 ,  A61P35/00 ,  C07K14/725 ,  C07K16/44 ,  C07K16/46 ,  C12N5/0783

CPC分类号： A61K35/17 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/365 ,  A61K31/519 ,  A61K38/1774 ,  A61P35/00 ,  C07K14/7051 ,  C07K16/44 ,  C07K16/46 ,  C12N5/0638 ,  C07K2317/622

摘要： The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells wherein the CAR T cells comprise a CAR and the CAR comprises an E2 anti-fluorescein antibody fragment, and administering to the patient a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.

公开(公告)号：US20190255109A1

公开(公告)日：2019-08-22

申请号：US16253562

申请日：2019-01-22

申请人： ENDOCYTE, INC. ,  PURDUE RESEARCH FOUNDATION ,  SEATTLE CHILDREN'S HOSPITAL (DBA SEATTLE CHILDREN'S RESEARCH INSTITUTE)

发明人： Philip Stewart LOW ,  Haiyan CHU ,  Yingjuan June LU ,  Christopher Paul LEAMON ,  Leroy W. WHEELER, II ,  Michael C. JENSEN ,  James MATTHAEI

IPC分类号： A61K35/17 ,  A61P35/00 ,  A61K31/519 ,  A61K31/365 ,  A61K9/00 ,  A61K38/17

摘要： The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells wherein the CAR T cells comprise a CAR and the CAR comprises an E2 anti-fluorescein antibody fragment, and administering to the patient a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.

公开(公告)号：US20210346431A1

公开(公告)日：2021-11-11

申请号：US16971801

申请日：2019-02-22

申请人： ENDOCYTE, INC. ,  PURDUE RESEARCH FOUNDATION ,  SEATTLE CHILDREN'S HOSPITAL (DBA SEATTLE CHILDREN'S RESEARCH INSTITUTE

发明人： Richard MESSMANN ,  Christopher Paul LEAMON ,  Haiyan CHU ,  Yingjuan June LU ,  Philip Stewart LOW ,  Michael C. JENSEN ,  James MATTHAEI ,  Navin Robert Charles PINTO ,  Julie Ruggieri PARK

IPC分类号： A61K35/17 ,  C07K14/705 ,  A61K47/55 ,  A61P35/00

摘要： The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells and administering to the patient a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.