Disclosed herein are systems and methods for multi-architecture computing. For example, in some embodiments, a computing system may include: a processor system including at least one first processor core having a first instruction set architecture (ISA); a memory device coupled to the processor system, wherein the memory device has stored thereon a first binary representation of a program for the first ISA; and control logic to suspend execution of the program by the at least one first processor core and cause at least one second processor core to resume execution of the program, wherein the at least one second processor core has a second ISA different from the first ISA; wherein the program is to generate data having an in-memory representation compatible with both the first ISA and the second ISA.