Systems and methods of holistically controlling a heating, ventilation, air conditioning, and refrigeration (HVACR) system and a multi-contaminant air cleaner (MCAC) are disclosed. The method includes sensing, via at least one HVACR sensor, at least one comfort parameter; sensing, via at least one MCAC sensor, at least one air-quality parameter; determining, via a controller, minimum air changes of the HVACR system based on the at least one comfort parameter; and determining, via the controller, equivalent air changes of the MCAC and an indoor air quality (IAQ) score based on the at least one air-quality parameter. The method also includes controlling an operation of the HVACR system and controlling an operation of the MCAC based on the determined air changes to optimize an energy consumption.